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The modern antipyretics, their action in health and disease

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Published by E.D. Vogel in Easton, Pa .
Written in English


  • Antipyretics

Book details:

Edition Notes

Statementby Isaac Ott
The Physical Object
Pagination52 p.. 2 fold. leaves of plates :
Number of Pages52
ID Numbers
Open LibraryOL24971701M

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Antipyretics such as aspirin have been widely used since the late 19th century, but the mechanisms by which they relieve fever have only been characterized in the last few decades. It is now clear that most antipyretics work by inhibiting the enzyme cyclooxygenase and reducing the levels of PGE 2 within the hypothalamus. Recently, other mechanisms of action for antipyretic drugs have been suggested, including their ability to reduce proinflammatory mediators, enhance anti-inflammatory Cited by: Fever has always been recognised as the major sign of infectious disease as well as being associated with other illnesses. The suggestion of publishing a volume dedicated exclusively to the subject of fever in the Handbook of Experimental Pharmacology series was one that greatly appealed to me, and I felt very honoured when I was invited to edit it.   Antipyretic agents have been used to lower febrile body temperature for well over two millennia. 1,2 Ancient Assyrian, Egyptian, and Greek physicians all apparently knew of and exploited the antipyretic property of extracts of the bark of the willow (Salix alba). 2 However, it was not until that the Reverend Edward Stone gave the first scientific description of the clinical benefits of Cited by: Fever can be hazardous to one's health. Despite the modern consensus view among fever biologists that fever has adaptive value in helping defend the host against infection [], the life-threatening nature of high fevers is universally ly, it is unresolved whether febrile elevations in body temperature per se can be lethal, but clearly the pathophysiological events accompanying.

What is Antipyretics – The Antipyretics drugs are a popular subcategory of are particularly meant to decrease the fever by lowering body temperature. The Antipyretic drugs have been since a long time to prevent and cure symptoms related to fever-like body pain and high temperature. Antipyretic is a medicine to reduce fever. Antipyretic medications include any nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen (paracetamol) and ibuprofen. Acetaminophen (paracetamol) and ibuprofen are often used to relieve the discomfort caused by a .   Dysmenorrhoea – menstrual pain; Some analgesic drugs have antipyretic activity which are aspirin and paracetemol. COX – cyclooxygenase is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and cological inhibition of COX can provide relief from the symptoms of inflammation and pain.   Here again, modern science has barely caught up with the wisdom of the Ancients, who were well aware of the strong link between psychological wellbeing and good health. In .

NCEH provides leadership to promote health and quality of life by preventing or controlling those diseases, birth defects, or disabilities resulting from interaction between people and the environment. Site has information/education resources on a broad range of topics, including asthma, birth defects, radiation, sanitation, lead in blood, and more. The Non-Steroidal Anti-inflammatory Drugs (NSAIDs) acts their antipyretic action mainly by inhibiting Prostaglandin E (PGE) production in the hypothalamus [24]. The hypothalamus works like a. Antipyretics & non-steroidal anti-inflammatory drugs (NSAIDS) reduce fever due to their anti-inflammatory action. In the present study, orally administered paracetamol ( mg/kg) significantly decreased baker's yeast-induced fever in rabbits. It has action on a specific cyclooxygenase (COX) isoenzyme in the CNS. In general, antipyretics take 30 to 60 minutes after administration to decrease temperature and discomfort. 2 Nonpharmacologic measures such as maintaining adequate fluid intake to replenish lost body fluids, wearing lightweight clothing, and maintaining a comfortable room temperature should also be incorporated into treatment. 2 During.